Killing Machine tells the tale of Franklyn J Hurt, an undercover agent for the Global Crime Task Force sent to infiltrate the criminal organization only known as The Syndicate Six. When his cover is blown, his wife taken and daughter murdered before his eyes, Frank wakes up barely a man, a torso with an unrecognizable face, hanging in a warehouse and used as an example for those who betray The Syndicate Six. However, Frank is rescued by Special Forces and taken to a secret installation where in its depths a massive facility of alien technology awaits. There Frank is given the bionic treatment. After rejecting his new duties, Frank seizes an opportunity to escape and go rogue to find his missing wife and seek revenge for the murder of his daughter using a new body that gives him the means to track down and destroy the killers.